Chronic Rumex Patientia Seed Feeding Improves Passive Avoidance Learning and Memory in Streptozotocin-Diabetic Rats

Chronic Rumex Patientia Seed Feeding Improves Passive Avoidance Learning and Memory in Streptozotocin-Diabetic Rats

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A B S T R A C T Introduction: Diabetes mellitus is accompanied with disturbances in learning, memory, and cognitive skills in the human society and experimental animals.Due to anti-diabetic and antioxidant activity of Rumex patientia (RP), this research study was conducted to B-12 Methylcobalamin evaluate the efficacy of chronic Rumex patientia feeding on alleviation of learning and memory disturbance in streptozotocindiabetic rats.Methods: Male Wistar rats were divided into control, diabetic, RP-treatedcontrol and -diabetic groups.For induction of diabetes, streptozotcin (STZ) was administered at a dose of 60 mg/Kg.

Meanwhile, RP-treated groups received RP seed powder mixed with standard pelleted food at a weight ratio of 6% for 4 weeks.For evaluation of learning and memory, initial latency (IL) and step-through latency (STL) were determined at the end of study using passive avoidance test.Results: It was found out that regarding initial latency, there was no significant difference among the groups.In addition, diabetic rats developed a significant impairment in retention and recall in passive avoidance test (p<0.

01), as it is evident by a lower STL.Furthermore, RP treatment of diabetic rats did produce a significant improvement in retention and recall (p<0.05).Discussion: Taken together, chronic RP APRICOT SCRUB feeding could improve retention and recall capability in passive avoidance test in STZ-diabetic rats.